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Page 1
Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation.
Kang LL, Zhang DM, Ma CH, Zhang JH, Jia KK, Liu JH, Wang R, Kong LD. Kang LL, et al. Sci Rep. 2016 Jun 8;6:27460. doi: 10.1038/srep27460. Sci Rep. 2016. PMID: 27270216 Free PMC article.
In this study, fructose-fed rats displayed metabolic syndrome with elevated serum ox-LDL, cardiac oxidative stress, inflammation and fibrosis. Scavenger receptor CD36, Toll-like receptor 4 (TLR4), TLR6, IL-1R-associated kinase 4/1 (IRAK4/1), nucleotide-binding domai …
In this study, fructose-fed rats displayed metabolic syndrome with elevated serum ox-LDL, cardiac oxidative stress, inflammation and fibrosi …
Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation.
Into T, Kiura K, Yasuda M, Kataoka H, Inoue N, Hasebe A, Takeda K, Akira S, Shibata K. Into T, et al. Cell Microbiol. 2004 Feb;6(2):187-99. doi: 10.1046/j.1462-5822.2003.00356.x. Cell Microbiol. 2004. PMID: 14706104
Mycoplasmal membrane diacylated lipoproteins not only initiate proinflammatory responses through Toll-like receptor (TLR) 2 and TLR6 via the activation of the transcriptional factor NF-kappaB, but also initiate apoptotic responses. ...Mycoplasma fermentans lipoproteins and …
Mycoplasmal membrane diacylated lipoproteins not only initiate proinflammatory responses through Toll-like receptor (TLR) 2 and TLR6 …
Toll-like receptors' pathway disturbances are associated with increased susceptibility to infections in humans.
Frazão JB, Errante PR, Condino-Neto A. Frazão JB, et al. Arch Immunol Ther Exp (Warsz). 2013 Dec;61(6):427-43. doi: 10.1007/s00005-013-0243-0. Epub 2013 Sep 22. Arch Immunol Ther Exp (Warsz). 2013. PMID: 24057516 Free article. Review.
TLRs are present in the plasma membrane (TLR1, TLR2, TLR4, TLR5, TLR6) and endosome (TLR3, TLR7, TLR8, TLR9) of leukocytes. TLRs and IL-1R are a family of receptors related to the innate immune response that contain an intracellular domain known as the Toll-IL-1R (TIR) dom …
TLRs are present in the plasma membrane (TLR1, TLR2, TLR4, TLR5, TLR6) and endosome (TLR3, TLR7, TLR8, TLR9) of leukocytes. TLRs and …
PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes.
Tiwari RL, Singh V, Singh A, Rana M, Verma A, Kothari N, Kohli M, Bogra J, Dikshit M, Barthwal MK. Tiwari RL, et al. J Lipid Res. 2014 Jul;55(7):1226-44. doi: 10.1194/jlr.M045658. Epub 2014 May 2. J Lipid Res. 2014. PMID: 24792928 Free PMC article.
In THP1 cells, Ox-LDL induced time-dependent secretory IL-1beta and IRAK1 activity; IRAK4, IRAK3, and CD36 protein expression; PKCdelta-JNK1 phosphorylation; and AP-1 activation. ...Ox-LDL-containing plasma induced PKCdelta and IRAK1 phosphorylation and IL-1beta production …
In THP1 cells, Ox-LDL induced time-dependent secretory IL-1beta and IRAK1 activity; IRAK4, IRAK3, and CD36 protein expression; PKCdel …
Toll-like receptor-associated sequence variants and prostate cancer risk among men of African descent.
Rogers EN, Jones DZ, Kidd NC, Yeyeodu S, Brock G, Ragin C, Jackson M, McFarlane-Anderson N, Tulloch-Reid M, Sean Kimbro K, Kidd LR. Rogers EN, et al. Genes Immun. 2013 Sep;14(6):347-55. doi: 10.1038/gene.2013.22. Epub 2013 May 9. Genes Immun. 2013. PMID: 23657238 Free PMC article.
Single and combined effects of SNPs in relation to PCA risk were assessed using age-adjusted logistic regression and entropy-based multifactor dimensionality reduction (MDR) models. Seven sequence variants detected in TLR6, TOLLIP (Toll-interacting protein), IRAK4 ( …
Single and combined effects of SNPs in relation to PCA risk were assessed using age-adjusted logistic regression and entropy-based multifact …
Tissue-specific mRNA expression profiles of human toll-like receptors and related genes.
Nishimura M, Naito S. Nishimura M, et al. Biol Pharm Bull. 2005 May;28(5):886-92. doi: 10.1248/bpb.28.886. Biol Pharm Bull. 2005. PMID: 15863899 Free article.
The mRNA expression of the 10 human TLRs was successfully detected in all of the tissues and in HeLa cells. TLR2, TLR3, TLR6, and TLR9 were consistently expressed in Hep G2 cells, but TLR1, TLR4, TLR5, TLR7, TLR8, and TLR10 showed no or very weak expression in these cells. …
The mRNA expression of the 10 human TLRs was successfully detected in all of the tissues and in HeLa cells. TLR2, TLR3, TLR6, and TLR …
TLR-1, TLR-2, and TLR-6 MYD88-dependent signaling pathway: A potential factor in the interaction of high-DNA fragmentation human sperm with fallopian tube epithelial cells.
Zandieh Z, Govahi A, Aghamajidi A, Raoufi E, Amjadi F, Aghajanpour S, Golestan M, Aflatoonian R. Zandieh Z, et al. Clin Exp Reprod Med. 2023 Mar;50(1):44-52. doi: 10.5653/cerm.2022.05610. Epub 2023 Feb 23. Clin Exp Reprod Med. 2023. PMID: 36935411 Free PMC article.
RESULTS: The PCR array data showed significantly higher TLR-1, TLR-2, TLR-3, TLR-6, interleukin 1alpha (IL-1alpha), IL-1beta, IL-6, IL-12, interferon alpha (IFN-alpha), IFN-beta, tumor necrosis factor alpha (TNF-alpha), CXCL8, GM-CSF, G-CSF, CD14, ELK1, IRAK1, IRAK2, IRAK4 …
RESULTS: The PCR array data showed significantly higher TLR-1, TLR-2, TLR-3, TLR-6, interleukin 1alpha (IL-1alpha), IL-1beta, IL-6, IL-12, i …
Membrane-bound toll-like receptors are overexpressed in peripheral blood and synovial fluid mononuclear cells of enthesitis-related arthritis category of juvenile idiopathic arthritis (JIA–ERA) patients and lead to secretion of inflammatory mediators.
Myles A, Rahman MT, Aggarwal A. Myles A, et al. J Clin Immunol. 2012 Jun;32(3):488-96. doi: 10.1007/s10875-011-9640-5. J Clin Immunol. 2012. PMID: 22302567
RNA levels of TLR1, TLR3, and TLRs 5-8 were measured in 24 ERA peripheral blood mononuclear cells (PBMC), 18 synovial fluid mononuclear cells (SFMC), and IRAK1, IRAK4, TRIF, TRAF3, and TRAF6 in 18 PBMC and 10 SFMC. IL-6 and IL-8 were measured in supernatants from ERA PBMC …
RNA levels of TLR1, TLR3, and TLRs 5-8 were measured in 24 ERA peripheral blood mononuclear cells (PBMC), 18 synovial fluid mononuclear cell …
Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk.
Sun J, Wiklund F, Hsu FC, Bälter K, Zheng SL, Johansson JE, Chang B, Liu W, Li T, Turner AR, Li L, Li G, Adami HO, Isaacs WB, Xu J, Grönberg H. Sun J, et al. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):480-5. doi: 10.1158/1055-9965.EPI-05-0645. Cancer Epidemiol Biomarkers Prev. 2006. PMID: 16537705
Although the single-nucleotide polymorphisms in IRAK1 and IRAK4 alone were not significantly associated with prostate cancer risk, one single-nucleotide polymorphism in IRAK4, when combined with the high-risk genotype at TLR6-1-10, conferred a significant exc …
Although the single-nucleotide polymorphisms in IRAK1 and IRAK4 alone were not significantly associated with prostate cancer risk, on …
Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome.
Martínez-Trillos A, Pinyol M, Navarro A, Aymerich M, Jares P, Juan M, Rozman M, Colomer D, Delgado J, Giné E, González-Díaz M, Hernández-Rivas JM, Colado E, Rayón C, Payer AR, Terol MJ, Navarro B, Quesada V, Puente XS, Rozman C, López-Otín C, Campo E, López-Guillermo A, Villamor N. Martínez-Trillos A, et al. Blood. 2014 Jun 12;123(24):3790-6. doi: 10.1182/blood-2013-12-543306. Epub 2014 Apr 29. Blood. 2014. PMID: 24782504 Free article.
Twenty-three patients (3.9%) had mutations, 19 in MYD88 (one with concurrent IRAK1 mutation), 2 TLR2 (one with concomitant TLR6 mutation), 1 IRAK1, and 1 TLR5. No mutations were found in IRAK2 and IRAK4. ...
Twenty-three patients (3.9%) had mutations, 19 in MYD88 (one with concurrent IRAK1 mutation), 2 TLR2 (one with concomitant TLR6 mutat …
12 results